Spravato is the brand name for esketamine nasal spray, made by Janssen. It is FDA-approved for adults with treatment-resistant depression, which generally means depression that has not responded adequately to at least two antidepressants, and for adults with major depressive disorder who have acute suicidal thoughts or behavior. Spravato is taken alongside a daily oral antidepressant rather than in place of one. It works through the glutamate system rather than serotonin, which gives it a distinct mechanism from most other antidepressants and a much faster onset. Some people notice a shift within hours or days, though the full benefit builds over weeks.
Treatment follows a set schedule. During the induction phase you come in twice a week for four weeks. After that, dosing drops to once a week for a month and then to every week or every other week based on how you are doing. Each visit involves administering the spray yourself in a quiet room and remaining under observation for at least two hours while staff check your blood pressure and how you feel. You cannot drive until the following day. Common effects during the session include dissociation, dizziness, nausea and sleepiness, all of which usually resolve before you leave. Because of these effects, Spravato is dispensed only through certified treatment centers in the REMS program. Stedfast Psychiatry is certified and offers Spravato at Boynton Beach, Palm Beach Gardens and Royal Palm Beach.
Where this applies at Stedfast
- Spravato (Esketamine) Treatment
- TRD
- Boynton Beach office
- Palm Beach Gardens office
- Royal Palm Beach office