Premenstrual dysphoric disorder is severe mood, irritability and anxiety symptoms in the week or two before menstruation that resolve after bleeding begins, affecting 3 to 8 percent of menstruating women. It is diagnosed by tracking symptoms across two cycles and treated with SSRIs taken continuously or only in the luteal phase, hormonal contraception containing drospirenone, and cognitive behavioral therapy. Stedfast Psychiatry treats premenstrual dysphoric disorder at 266 NW Peacock Blvd in Port St. Lucie and by video across Florida; new patients call (561) 295-4629.
Premenstrual Dysphoric Disorder at our Port St. Lucie office
For premenstrual dysphoric disorder treatment, residents of Tradition, Torino, Lake Charles and PGA Village and Jensen Beach, Palm City, Vero Beach and Hutchinson Island are usually within a short drive. The office is in St.
Call (561) 295-4629 to book, or request an appointment online and we will call you back. The office is open weekdays 8:00 AM to 5:00 PM. The office is in St. Lucie West, immediately east of I-95.
The Port St. Lucie office is an entry point to Stedfast Psychiatry's Deep TMS and Spravato programs. Treatment sessions run at our Palm Beach Gardens TMS center and the Palm Beach Gardens Spravato rooms, roughly 55 and 55 minutes away; the evaluation, the screening scales and the prior authorization all happen here.
Who you will see in Port St. Lucie
The Port St. Lucie team includes psychiatric nurse practitioners Kathryn Segura, Ryan Loli and Carline Grand Pierre and physician assistants Kevin Myirski, Elco Marquez and Taylor Kane. Visits in Spanish are available with Elco Marquez. Children and teens are seen by Kevin Myirski, Kathryn Segura and Taylor Kane. Ryan Loli and Carline Grand Pierre focus on adults 65 and older, including facility residents.
Kevin Myirski, PA-C
Physician Assistant · Adults and teens 15+; younger on request
Kathryn Segura, PMHNP-BC
Psychiatric Nurse Practitioner · Adults and teens 16+
Elco Marquez, PA-C
Physician Assistant · Adults 18+ · English, Spanish
Ryan Loli, PMHNP-BC
Psychiatric Nurse Practitioner · Adults 65+ (facility visits only)
Carline Grand Pierre
Psychiatric Nurse Practitioner · Adults 65+ (facility visits only)
Taylor Kane, PA-C
Physician Assistant · Adults and teens 17+
Signs of premenstrual dysphoric disorder
- Marked irritability, anger or increased conflict in the week before your period
- Depressed mood, hopelessness or self-critical thoughts
- Anxiety, tension or feeling on edge
- Sudden mood swings, tearfulness or sensitivity to rejection
- Loss of interest in usual activities
- Difficulty concentrating
- Fatigue, changes in appetite or food cravings
- Sleeping too much or too little
How we diagnose it
PMDD is diagnosed by the pattern over time, not by a single visit or a blood test. We ask you to track symptoms daily for two menstrual cycles using the Daily Record of Severity of Problems (DRSP) or a tracking app, which confirms that symptoms are confined to the luteal phase and clear after menstruation begins. This distinguishes PMDD from premenstrual exacerbation of an underlying condition such as depression, anxiety, bipolar disorder or ADHD, where symptoms are present all month and worsen before the period; that pattern is treated differently. We screen with the PHQ-9 and GAD-7 at different points in the cycle, review your reproductive history, contraception and any prior treatment, and check thyroid function and a complete blood count when fatigue or other physical symptoms suggest a medical contributor. With your consent we coordinate with your gynecologist.
PMDD affects an estimated 3 to 8 percent of women of reproductive age, and up to 20 percent experience premenstrual symptoms severe enough to impair functioning.
Source: American College of Obstetricians and Gynecologists; American Psychiatric Association, DSM-5-TR
SSRIs reduce PMDD symptoms in about 60 to 75 percent of women, compared with roughly 30 percent for placebo, and are effective with luteal-phase-only dosing.
Source: Cochrane Review, Marjoribanks et al., 2013
PMDD was added to DSM-5 as a depressive disorder in 2013 and to the WHO's ICD-11 in 2019.
Source: American Psychiatric Association; World Health Organization
Women with PMDD have substantially elevated rates of suicidal ideation and attempts compared with women without the disorder.
Source: Pilver et al., Archives of Women's Mental Health, 2013
Treatment for premenstrual dysphoric disorder in Port St. Lucie
Medication management
SSRIs are first-line and work unusually fast in PMDD, often within one to three days rather than weeks. Fluoxetine, sertraline and paroxetine CR are FDA-approved for PMDD, and escitalopram and citalopram are also effective. They can be taken continuously, or only during the luteal phase (starting at ovulation, about 14 days before the period, and stopping when bleeding begins), or in a symptom-onset approach starting when symptoms appear; luteal-phase dosing reduces side effects and is preferred by many women. Hormonal options, coordinated with your gynecologist, include combined oral contraceptives containing drospirenone (Yaz is FDA-approved for PMDD) taken continuously to suppress cycling. For severe PMDD unresponsive to these, GnRH agonists with add-back hormone therapy produce a temporary medical menopause and are used under specialist care. Calcium 1,200 mg daily has modest evidence for premenstrual symptoms. We review response each cycle and adjust the dosing strategy to fit your pattern and side effects.
Psychotherapy
Cognitive behavioral therapy for PMDD helps you anticipate the luteal phase, plan around it, challenge the self-critical and catastrophic thoughts that intensify during it, manage interpersonal conflict, and reduce the shame that often follows a bad week. It is effective alone for milder cases and improves outcomes when combined with medication. Partners and family often benefit from understanding the cyclical pattern, and we involve them when you wish. Therapy also addresses the trauma, depression or anxiety that frequently accompany PMDD.
What to expect
Your first visit is a 45 to 60 minute evaluation, in person or by video, where we review your history and set up two cycles of symptom tracking. If your pattern is already clear and symptoms are severe, we may start treatment while tracking continues. Follow-ups are every four to six weeks, timed to cover at least one full cycle, and most can be done by telehealth from anywhere in Florida or South Carolina. We coordinate with your gynecologist on hormonal options and with your other providers as needed.
The complete guide, including causes, subtypes and research, is on our Premenstrual Dysphoric Disorder page.
Emergency and crisis resources near Port St. Lucie
In an emergency, call 911 or go to Cleveland Clinic Tradition Hospital Emergency Department (10000 SW Innovation Way, Port St). The 988 Suicide and Crisis Lifeline is available by call or text 24 hours a day. HCA Florida St. Lucie Hospital Emergency Room and 988 Suicide and Crisis Lifeline are also listed on the Port St. Lucie office page.
Frequently asked questions
Who provides premenstrual dysphoric disorder treatment at the Port St. Lucie office?
The Port St. Lucie team includes psychiatric nurse practitioners Kathryn Segura, Ryan Loli and Carline Grand Pierre and physician assistants Kevin Myirski, Elco Marquez and Taylor Kane. Visits in Spanish are available with Elco Marquez. Every provider works under psychiatrist oversight and the same evaluation standard: about an hour for a first visit, validated screening scales, and a written plan.
Can I be seen by video instead of coming to Port St. Lucie?
Yes. Stedfast Psychiatry providers are licensed in Florida and offer video visits for evaluations and follow-ups. Some situations, including certain controlled-substance prescriptions and first visits for young children, require an in-person appointment at 266 NW Peacock Blvd.
Does the Port St. Lucie office take my insurance?
We accept most major commercial plans and Medicare. Call (561) 295-4629 with your member ID and we will verify benefits before the visit. Self-pay new-patient evaluations are $185.
How soon can a new patient be seen in Port St. Lucie?
Most new patients are scheduled within one to two weeks. If you need to be seen sooner, ask about a video visit; those often open up within days. If you are in crisis, call or text 988 or go to the nearest emergency room rather than waiting.
Can I get Deep TMS or Spravato as a Port St. Lucie patient?
Yes. Stedfast Psychiatry is licensed for both. Your Port St. Lucie provider does the evaluation and the prior authorization; treatment sessions are scheduled at our Palm Beach Gardens TMS center and the Palm Beach Gardens Spravato rooms.
What is the difference between PMS and PMDD?
PMS involves mild to moderate physical and mood symptoms before a period that are annoying but manageable, and it affects most women at some point. PMDD is defined by severe mood symptoms, particularly irritability, depression, anxiety and mood swings, that significantly impair work, relationships or daily life and that resolve after bleeding starts. The distinction is severity and impairment, confirmed by tracking two cycles. If the premenstrual week regularly damages your life, it is not ordinary PMS.
Why would an antidepressant help if PMDD is hormonal?
Because the problem is how the brain's serotonin and GABA systems respond to normal hormone shifts, not the hormones themselves. SSRIs correct that response and, in PMDD, work within days rather than the weeks needed in depression, which is why they can be taken only during the luteal phase. Hormonal treatments work by stopping the cycle altogether. Both are valid and we choose based on your preferences, contraception needs and side-effect profile.
Nearby Stedfast offices
If you are in crisis, call or text 988 or go to the nearest emergency room. Educational content; individual results vary. Reviewed by Dr. David Husted, board-certified psychiatrist.